Worm load and septal fibrosis of the liver in Capillaria hepatica-infected rats
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چکیده
منابع مشابه
Worm load and septal fibrosis of the liver in Capillaria hepatica-infected rats.
Inocula, varying from 15 to 1,000 embryonated Capillaria hepatica eggs, were administered to young adult rats by gastric tube, in an attempt to investigate the influence of worm load in the production of septal fibrosis of the liver. Low doses of 15, 30 or 50 eggs were sufficient to produce septal fibrosis, but it appeared with variable degrees of intensity and always with focal distribution. S...
متن کاملImmunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats.
Rats infected with the helminth Capillaria hepatica regularly develop septal fibrosis of the liver similar to that induced by repeated ip injections of pig serum. Fibrosis starts when the focal parasitic lesions begin to show signs of resorption, thus suggesting an immunologically mediated pathogenesis of this fibrosis. To explore this possibility, the development of C. hepatica-related hepatic...
متن کاملDynamics of Capillaria-hepatica-induced hepatic septal fibrosis in rats.
INTRODUCTION The pathogenesis of septal hepatic fibrosis, induced in rats by Capillaria hepatica infection, was studied with the aid of a large collection of stored paraffin blocks, representative of the different evolutive phases of fibrosis which appeared in 100% of infected rats. METHODS Studies were conducted involving histology, immunohistochemistry, immunofluorescence and morphometric m...
متن کاملImmunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats.
Systhematized septal fibrosis of the liver can be induced in rats either by repeated intraperitoneal injections of pig-serum or by Capillaria hepatica infection. The relationship between these two etiological factors, as far as hepatic fibrosis is concerned, is not known, and present investigation attempts to investigate it. C. hepatica-induced septal fibrosis of the liver was considerably inhi...
متن کاملCapillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses.
Capillaria hepatica causes two main lesions in the liver of rats: multifocal chronic inflammation, directly related to the presence of disintegrating parasites and their eggs, and a process of systematized septal fibrosis. The comparative behavior of these two lesions was investigated in rats experimentally infected with 600 embryonated eggs, following either corticosteroid treatment or specifi...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 2001
ISSN: 0074-0276
DOI: 10.1590/s0074-02762001000700020